No matter if you arrive to Rome by train, plane, bus or car, go to the Main Railway Station TERMINI, which is well linked with all airports and train/bus stations.
Once at Termini, with the train at your back, go out by the left side of the Station. Then look for any of these streets: via Gioberti, via Cattaneo, via Rattazzi.
Walk any of them for two blocks and you should find via Napoleone III. Just look for number 58 (ring Astro Hostel Rome).